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活性蛋白
- Recombinant Human Tumor necrosis factor receptor superfamily member 17(TNFRSF17),partial (Active)
- 恒遠生物蛋白表達平臺建立了從原核到真核四大重組表達系統(tǒng),并建立無細胞表達系統(tǒng),擁有基于昆蟲病毒外膜蛋白展示的蛋白表達技術(shù)、膜蛋白表達技術(shù)等一系列蛋白表達及純化技術(shù),有能力制備各種高難度蛋白。
Recombinant Human Tumor necrosis factor receptor superfamily member 17(TNFRSF17),partial (Active)
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貨號：HYB-100151
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規(guī)格：
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圖片：
產(chǎn)品詳情
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純度：Greater than 90% as determined by SDS-PAGE.
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內(nèi)毒素：Less than 1.0 EU/ug as determined by LAL method.
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生物活性：①Measured by its binding ability in a functional ELISA. Immobilized BCMA at 2 μg/ml can bind Anti-BCMA recombinant antibody, the EC50 of human BCMA protein is 1.912-2.488 ng/ml.②Measured by its binding ability in a functional ELISA. Immobilized TNFSF13B (CSB-MP897523HU1) at 10 μg/ml can bind human BCMA, the EC50 of human BCMA protein is 221.3-298.6 ng/ml. ③Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.
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基因名：TNFRSF17
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別名：B cell maturation antigen; B cell maturation factor; B cell maturation protein; B-cell maturation protein; BCM; BCMA; CD269; CD269 antigen; TNFRSF17; TNR17_HUMAN; Tumor necrosis factor receptor superfamily member 17
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分子結(jié)構(gòu)：
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種屬：Homo sapiens (Human)
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蛋白長度：Partial
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來源：Mammalian cell
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分子量：34.8 kDa
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表達區(qū)域：1-54aa
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氨基酸序列MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNA
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蛋白標(biāo)簽：C-terminal hFc-tagged
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產(chǎn)品提供形式：Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
緩沖液：Lyophilized from a 0.2 μm filtered PBS, 6% Trehalose, pH 7.4
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儲存條件：Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質(zhì)期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
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產(chǎn)品描述：
Recombinant Human Tumor Necrosis Factor Receptor Superfamily Member 17 (TNFRSF17) is a partial-length receptor produced in mammalian cells. A DNA sequence encoding the TNFRSF17 (1-54aa) was fused with an Fc-tag at C-terminal. Recombinant TNFRSF17 finds applications in studies involving cancer cells.
TNFRSF17 is a cell surface receptor usually expressed on B-cells. It is activated by ligands from the TNF 13b superfamily and TRAF family. On activation, it transmits signals that play a part in the activation of NF-kb and JNK/MAPK8 pathways.
In T-cell acute lymphoblastic leukemia and multiple myeloma, chromosomal errors in TNFRSF17 have been linked to aberrant activation of NF-kb and JNK. Aberrant activation of NF-kb and JNK pathways contributes to cancer-cell proliferation, metastasis, angiogenesis, and the inhibition of cancer-cell apoptosis.
The product has a molecular weight of 34.8 kDa, and purity levels over 90%, as verified using discontinuous SDS-PAGE. Its activity is verified with ELISA and LSPR assay.
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